Solid Phase Immunoassays

News and Announcements

highly sensitized (1)

  • Using donor exchange paradigms with desensitization to enhance transplant rates among highly sensitized patients.

    Posted by Immunoassays on September 2, 2014 at 2:31pm

    Robert A. Montgomery, Bonnie E. Lonze and Annette M. Jackson

    Purpose of review
    Many sensitized patients have willing live donors but are unable to use them because of a human leukocyte antigen (HLA) incompatibility. The options for these patients include: remaining on the deceased-donor list, entering a kidney-paired donation scheme, or undergoing desensitization with high-dose IVIg or plasmapheresis and low-dose IVIg.
    Recent findings
    Mathematical simulations verified by actual data from several national kidney-paired donation (KPD) programs has shed light on which donor/recipient phenotypes are likely to benefit from each transplant modality. Pairs that are easy to match are likely to receive compatible kidneys in a KPD. Those who are hard to match may be better served by desensitization. The phenotype which is both hard to match and hard to desensitize due to board and strong…

    Read more…
RSS